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Original Article
Online Published: 07 Jul 2026
 


Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study

Mohammad Irfan, Shrish Bhatnagar, Shalini Verma.


Abstract
Background: Zinc supplementation is recommended in both acute and persistent diarrhea; however, comparative data on longitudinal biochemical response between these conditions are limited.

Methods: This prospective observational study was conducted at the pediatric department of a tertiary care centre in Northern India, which enrolled 72 children: 36 with acute diarrhea (Group A) and 36 with persistent diarrhea (Group B). All participants received oral zinc sulphate syrup providing 20 mg elemental zinc daily for 14 days. Serum zinc was measured at Day 1,14,28. Longitudinal analysis was performed using a linear mixed-effects model with time and group as fixed effects and subject as a random effect.

Results: A gradual increase in serum zinc was observed in both groups. No statistically significant group-time interaction was detected, indicating similar trajectories.

Conclusions: Zinc supplementation results in a modest but consistent increase in serum zinc levels in both groups. No significant difference was detected between acute and persistent diarrhea. These findings do not suggest a need for higher dosing; however, further adequately powered studies are warranted.

Key words: Zinc supplementation, acute diarrhea, persistent diarrhea, serum zinc levels, pediatric diarrhea


 
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Pubmed Style

Irfan M, Bhatnagar S, Verma S. Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. Sudan J Paed. Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005

Web Style

Irfan M, Bhatnagar S, Verma S. Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. https://sudanjp.com//?mno=317488 [Access: July 07, 2026]. doi:10.24911/SJP.106-1776246005

AMA (American Medical Association) Style

Irfan M, Bhatnagar S, Verma S. Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. Sudan J Paed. Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005


Vancouver/ICMJE Style

Irfan M, Bhatnagar S, Verma S. Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. Sudan J Paed, [cited July 07, 2026]; Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005


Harvard Style

Irfan, M., Bhatnagar, . S. & Verma, . S. (0) Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. Sudan J Paed, Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005


Turabian Style

Irfan, Mohammad, Shrish Bhatnagar, and Shalini Verma. 0. Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. Sudanese Journal of Paediatrics, Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005


Chicago Style

Irfan, Mohammad, Shrish Bhatnagar, and Shalini Verma. "Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study." Sudanese Journal of Paediatrics Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005


MLA (The Modern Language Association) Style

Irfan, Mohammad, Shrish Bhatnagar, and Shalini Verma. "Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study." Sudanese Journal of Paediatrics Online First: 07 Jul, 2026. Web. 07 Jul 2026 doi:10.24911/SJP.106-1776246005


APA (American Psychological Association) Style

Irfan, M., Bhatnagar, . S. & Verma, . S. (0) Serum Zinc Response to Standard Therapy in Acute versus Persistent Pediatric Diarrhea: A Prospective Comparative Study. Sudanese Journal of Paediatrics, Online First: 07 Jul, 2026. doi:10.24911/SJP.106-1776246005




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