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Case Report
Online Published: 28 Dec 2025
 


Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review

Haydar El Hadi Babikir, Imad Yassin Saadeldin, Anas Osman Ahmed Hamdoun.


Abstract
Neurocutaneous melanosis (NCM) is a congenital disorder characterised by large or multiple melanocytic naevi and pigment cell tumours of the leptomeninges. Malignant leptomeningeal melanoma occurs in over half of the cases and has a poor prognosis. This disorder stems from melanoblast abnormalities and NRAS gene mutations. Magnetic resonance imaging (MRI) cannot distinguish between benign and malignant cases. Positron emission tomography-computed tomography (PET-CT) may detect malignancies, whereas computed tomography (CT) has limited use. We report on a 34-month-old Sudanese female patient, diagnosed with neurocutaneous melanosis, meeting the diagnostic criteria through dermatological evaluation and brain MRI. Melanoma associated with NCM is infrequently documented, presenting significant diagnostic and therapeutic challenges that necessitate accurate diagnosis and treatment.

Key words: giant congenital melanocytic nevus, neurocutaneous melanosis, Sudanese girl


 
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How to Cite this Article
Pubmed Style

Babikir HEH, Saadeldin IY, Hamdoun AOA. Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. Sudan J Paed. Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515

Web Style

Babikir HEH, Saadeldin IY, Hamdoun AOA. Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. https://sudanjp.com//?mno=237383 [Access: December 29, 2025]. doi:10.24911/SJP.106-1736714515

AMA (American Medical Association) Style

Babikir HEH, Saadeldin IY, Hamdoun AOA. Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. Sudan J Paed. Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515


Vancouver/ICMJE Style

Babikir HEH, Saadeldin IY, Hamdoun AOA. Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. Sudan J Paed, [cited December 29, 2025]; Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515


Harvard Style

Babikir, H. E. H., Saadeldin, . I. Y. & Hamdoun, . A. O. A. (0) Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. Sudan J Paed, Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515


Turabian Style

Babikir, Haydar El Hadi, Imad Yassin Saadeldin, and Anas Osman Ahmed Hamdoun. 0. Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. Sudanese Journal of Paediatrics, Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515


Chicago Style

Babikir, Haydar El Hadi, Imad Yassin Saadeldin, and Anas Osman Ahmed Hamdoun. "Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review." Sudanese Journal of Paediatrics Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515


MLA (The Modern Language Association) Style

Babikir, Haydar El Hadi, Imad Yassin Saadeldin, and Anas Osman Ahmed Hamdoun. "Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review." Sudanese Journal of Paediatrics Online First: 28 Dec, 2025. Web. 29 Dec 2025 doi:10.24911/SJP.106-1736714515


APA (American Psychological Association) Style

Babikir, H. E. H., Saadeldin, . I. Y. & Hamdoun, . A. O. A. (0) Giant congenital melanocytic nevi and neurocutaneous melanosis in a Sudanese girl: Case report and literature review. Sudanese Journal of Paediatrics, Online First: 28 Dec, 2025. doi:10.24911/SJP.106-1736714515




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