E-ISSN 1858-8360 | ISSN 0256-4408
 

Original Article

Online Publishing Date: 09 / 05 / 2020

 


The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis

Abdelaziz Elamin, Hashim Jawad.


Abstract
Objective: to report two cases of resistance to thyroid hormone to increase the awareness of this syndrome, which is frequently is diagnosed and incorrectly treated.
Methods: we described two siblings, both of whom were diagnosed as having thyrotoxicosis and one of them was treated with carbamazole and subsequently developed hypothyroidism. Both patients showed features of resistance to thyroid hormone and required additional L-thyroxine to normalize the thyroid stimulating hormone level while remaining clinically euthyroid.
Results: Laboratory evaluation revealed increased serum thyroxine and tri-iodothyroxine levels as well as increased thyroid stimulating hormone (TSH) levels. The free alpha subunit/TSH ratio was normal, and CT of the pituitary gland showed no tumour. Metabolic studies using graded doses of tri-iodothyroxine supported the diagnosis.
Conclusion: The two patients have resistance to thyroid hormone but were erroneously diagnosed as thyrotoxic and one of them inappropriately treated. Patients with elevated plasma levels of thyroid hormones with high or normal TSH level need careful evaluation of the hypothalamic-pituitary function & peripheral action of thyroid hormones.

Key words: Thyroid function, hypothyroidism, TSH, goitre


 
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How to Cite this Article
Pubmed Style

Elamin A, Jawad H. The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. Sudan J Paed. Online First: 09 May, 2020.


Web Style

Elamin A, Jawad H. The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. https://sudanjp.com//?mno=105923 [Access: February 07, 2024].


AMA (American Medical Association) Style

Elamin A, Jawad H. The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. Sudan J Paed. Online First: 09 May, 2020.



Vancouver/ICMJE Style

Elamin A, Jawad H. The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. Sudan J Paed, [cited February 07, 2024]; Online First: 09 May, 2020.



Harvard Style

Elamin, A. & Jawad, . H. (2007) The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. Sudan J Paed, Online First: 09 May, 2020.



Turabian Style

Elamin, Abdelaziz, and Hashim Jawad. 2007. The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. Sudanese Journal of Paediatrics, Online First: 09 May, 2020.



Chicago Style

Elamin, Abdelaziz, and Hashim Jawad. "The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis." Sudanese Journal of Paediatrics Online First: 09 May, 2020.



MLA (The Modern Language Association) Style

Elamin, Abdelaziz, and Hashim Jawad. "The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis." Sudanese Journal of Paediatrics Online First: 09 May, 2020. Web. 07 Feb 2024



APA (American Psychological Association) Style

Elamin, A. & Jawad, . H. (2007) The syndrome of resistance to thyroid hormone, misdiagnosed as thyrotoxicosis. Sudanese Journal of Paediatrics, Online First: 09 May, 2020.





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