E-ISSN 1858-8360 | ISSN 0256-4408
 

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An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.

Imadeldin M Taj Eldin; Majed M Abdalmutalab; Haydar E Bikir.

Abstract
Haemostasis is the process of forming clots in the walls of damaged blood vessels to prevent abnormal bleeding and to maintain intravascular blood in a fluid state. Fenugreek is largely universal staple herb, popular throughout history and it has been consumed for treatment of different disorders. We aimed to study the possible anticoagulant effect of Fenugreek aqueous extract in vitro by using blood samples of normal individuals. In vitro anticoagulant effects of Fenugreek aqueous extract (5%) in different volumes (25, 50 and 75 μL) were examined in the blood samples of normal individuals by measuring prothrombin time (PT). The aqueous extract of Fenugreek was found to inhibit coagulation process in vitro and significantly prolonged prothrombin time in a dose-dependent manner. Fenugreek aqueous extract in different concentrations inhibits clot formation and increases prothrombin time. Subject to further studies on efficacy and safety, It can well be used, in the future, as a supplementary anticoagulant agent in cardiovascular diseases and to prevent hypercoagulable states.

Key words: Anticoagulant; Fenugreek; Haemostasis; Medicinal plants; Prothrombin time; Sudan


 
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Pubmed Style

Eldin IMT, Abdalmutalab MM, Bikir HE. An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. Sudan J Paed. 2013; 13(2): 52-6.


Web Style

Eldin IMT, Abdalmutalab MM, Bikir HE. An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. http://www.sudanjp.com/?mno=280717 [Access: November 24, 2021].


AMA (American Medical Association) Style

Eldin IMT, Abdalmutalab MM, Bikir HE. An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. Sudan J Paed. 2013; 13(2): 52-6.



Vancouver/ICMJE Style

Eldin IMT, Abdalmutalab MM, Bikir HE. An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. Sudan J Paed. (2013), [cited November 24, 2021]; 13(2): 52-6.



Harvard Style

Eldin, I. M. T., Abdalmutalab, . M. M. & Bikir, . H. E. (2013) An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. Sudan J Paed, 13 (2), 52-6.



Turabian Style

Eldin, Imadeldin M Taj, Majed M Abdalmutalab, and Haydar E Bikir. 2013. An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. Sudanese Journal of Paediatrics, 13 (2), 52-6.



Chicago Style

Eldin, Imadeldin M Taj, Majed M Abdalmutalab, and Haydar E Bikir. "An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.." Sudanese Journal of Paediatrics 13 (2013), 52-6.



MLA (The Modern Language Association) Style

Eldin, Imadeldin M Taj, Majed M Abdalmutalab, and Haydar E Bikir. "An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.." Sudanese Journal of Paediatrics 13.2 (2013), 52-6. Print.



APA (American Psychological Association) Style

Eldin, I. M. T., Abdalmutalab, . M. M. & Bikir, . H. E. (2013) An in vitro anticoagulant effect of Fenugreek (Trigonella foenum-graecum) in blood samples of normal Sudanese individuals.. Sudanese Journal of Paediatrics, 13 (2), 52-6.





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