E-ISSN 1858-8360 | ISSN 0256-4408
 

Original Article 


Aetiologies and clinical patterns of hypopituitarism in Sudanese children

Samar S. Hassan, Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, Mohamed A. Abdullah.


Abstract
There is paucity of reported information regarding aetiology and clinical profile of hypopituitarism from resource-limited countries particularly in populations with high rates of consanguineous marriages. Here, we are reporting the first data on this aspect from Sudan. This is a descriptive, retrospective, hospital-based study, carried out in the two main paediatric endocrinology centres in
Sudan (Gafaar Ibn Auf Paediatric Tertiary Hospital and Soba University Hospital, Khartoum) from January 2006 up to December 2014. Patients’ records were reviewed for relevant demographical, clinical, hormonal and radiological data using pretested study
forms. The study included 156 patients. One hundred and one patients were males (M: F = 1.8:1). The commonest age groups were
adolescents (57.7%). Consanguinity was found in 77.8% of patients overall and 91% of patients with congenital aetiologies. The commonest clinical presentation was short stature (93.5%). Congenital causes (86.5%) were more prevalent than acquired causes
(13.5%). There were six family clusters with multiple pituitary hormone deficiencies (MPHD) and three families with isolated
growth hormone (GH) deficiency (IGHD). Most of the congenital cases with MPHD were phenotypic for PROP1 gene mutation (77.5% of sporadic cases and 50% of familial cases). Craniopharyngioma was the commonest of the acquired causes (10.2%). GH was the most frequent hormone deficient (89.7%). Abnormal Magnetic resonance imaging brain findings were significantly seen more in MPHD in comparison to IGHD. The genetic forms of hypopituitarism in populations with high rates of consanguineous marriage like Sudan may be higher than those reported internationally. Molecular genetic studies are, therefore, highly recommended.

Key words: Multiple pituitary hormone deficiency; Isolated growth hormone deficiency; Hypopituitarism; Children; Sudan.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Samar S. Hassan
Articles by Renson Mukhwana
Articles by Salwa Musa
Articles by Areej A. B. Ibrahim
Articles by Omer Babiker
Articles by Mohamed A. Abdullah
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed. 2021; 21(1): 53-60. doi:10.24911/SJP.106-1588448825


Web Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. https://sudanjp.com//?mno=103965 [Access: February 09, 2024]. doi:10.24911/SJP.106-1588448825


AMA (American Medical Association) Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed. 2021; 21(1): 53-60. doi:10.24911/SJP.106-1588448825



Vancouver/ICMJE Style

Hassan SS, Mukhwana R, Musa S, Ibrahim AAB, Babiker O, Abdullah MA. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed. (2021), [cited February 09, 2024]; 21(1): 53-60. doi:10.24911/SJP.106-1588448825



Harvard Style

Hassan, S. S., Mukhwana, . R., Musa, . S., Ibrahim, . A. A. B., Babiker, . O. & Abdullah, . M. A. (2021) Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudan J Paed, 21 (1), 53-60. doi:10.24911/SJP.106-1588448825



Turabian Style

Hassan, Samar S., Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, and Mohamed A. Abdullah. 2021. Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudanese Journal of Paediatrics, 21 (1), 53-60. doi:10.24911/SJP.106-1588448825



Chicago Style

Hassan, Samar S., Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, and Mohamed A. Abdullah. "Aetiologies and clinical patterns of hypopituitarism in Sudanese children." Sudanese Journal of Paediatrics 21 (2021), 53-60. doi:10.24911/SJP.106-1588448825



MLA (The Modern Language Association) Style

Hassan, Samar S., Renson Mukhwana, Salwa Musa, Areej A. B. Ibrahim, Omer Babiker, and Mohamed A. Abdullah. "Aetiologies and clinical patterns of hypopituitarism in Sudanese children." Sudanese Journal of Paediatrics 21.1 (2021), 53-60. Print. doi:10.24911/SJP.106-1588448825



APA (American Psychological Association) Style

Hassan, S. S., Mukhwana, . R., Musa, . S., Ibrahim, . A. A. B., Babiker, . O. & Abdullah, . M. A. (2021) Aetiologies and clinical patterns of hypopituitarism in Sudanese children. Sudanese Journal of Paediatrics, 21 (1), 53-60. doi:10.24911/SJP.106-1588448825





Most Viewed Articles
Most Accessed Articles

  • Rheumatic heart disease in North Darfur: an alarmingly high burden and control initiative
    Nagwa Salih, Ishag Eisa, Daresalam Ishag, Intisar Ibrahim, Sulafa Ali
    Sudan J Paed. 2018; 18(1): 24-27
    » Abstract » doi: 10.24911/SJP.2018.1.4

  • Feeding growth restricted premature neonates: a challenging perspective
    Siba Prosad Paul, Emily Natasha Kirkham, Katherine Amy Hawton, Paul Anthony Mannix
    Sudan J Paed. 2018; 18(2): 5-14
    » Abstract » doi: 10.24911/SJP.106-1519511375

  • Congenital brain malformations in Sudanese children: an outpatient-based study
    Inaam Noureldyme Mohammed, Soad Abdalaziz Suliman, Maha A Elseed, Ahlam Abdalrhman Hamed, Mohamed Osman Babiker, Shaimaa Osman Taha
    Sudan J Paed. 2018; 18(1): 48-56
    » Abstract » doi: 10.24911/SJP.2018.1.7

  • Evaluation of Science. [eng]
    Adnan Mahmmood Usmani; Sultan Ayoub Meo
    Sudan J Paed. 2011; 11(1): 6-7
    » Abstract

  • Medical education and services in an extreme environment
    Mustafa Abdalla M. Salih, Mohammed Osman Swar
    Sudan J Paed. 2018; 18(1): 2-5
    » Abstract » doi: 10.24911/SJP.2018.1.1

  • Most Downloaded
    Top Downloaded Articles

  • The role of micronutrients in thyroid dysfunction
    Amir Babiker, Afnan Alawi, Mohsen Al Atawi, Ibrahim Al Alwan
    Sudan J Paed. 2020; 20(1): 13-19
    » Abstract » doi: 10.24911/SJP.106-1587138942

  • Why mothers are not exclusively breast feeding their babies till 6 months of age? Knowledge and practices data from two large cities of the Kingdom of Saudi Arabia
    Hafsa Raheel, Shabana Tharkar
    Sudan J Paed. 2018; 18(1): 28-38
    » Abstract » doi: 10.24911/SJP.2018.1.5

  • Relactation in lactation failure and low milk supply
    Anita Mehta, Arvind Kumar Rathi, Komal Prasad Kushwaha, Abhishek Singh
    Sudan J Paed. 2018; 18(1): 39-47
    » Abstract » doi: 10.24911/SJP.2018.1.6

  • Inborn errors of metabolism associated with hyperglycaemic ketoacidosis and diabetes mellitus: narrative review
    Majid Alfadhel, Amir Babiker
    Sudan J Paed. 2018; 18(1): 10-23
    » Abstract » doi: 10.24911/SJP.2018.1.3

  • Neonatal polycythaemia
    Bashir Abdrhman Bashir, Suhair Abdrahim Othman
    Sudan J Paed. 2019; 19(2): 81-83
    » Abstract » doi: 10.24911/SJP.106-1566075225

  • Most Cited Articles
    Most Cited Articles

  • Anti-diabetic medications: How to make a choice?
    Amir Babiker, Mohammed Al Dubayee
    Sudan J Paed. 2017; 17(2): 11-20
    » Abstract » doi: 10.24911/SJP.2017.2.12
    Cited : 8 times [Click to see citing articles]

  • Commitment to the wellbeing of children worldwide. [eng]
    Mustafa Abdalla M Salih; Satti Abdelrahim Satti
    Sudan J Paed. 2011; 11(2): 4-5
    » Abstract
    Cited : 4 times [Click to see citing articles]

  • Pattern of malaria in hospitalized children in Khartoum state
    Hasan Awadalla Hashim, Eltigani Mohamed Ahmed Ali
    Sudan J Paed. 2017; 17(2): 35-41
    » Abstract » doi: 10.24911/SJP.2017.2.4
    Cited : 4 times [Click to see citing articles]

  • The role of micronutrients in thyroid dysfunction
    Amir Babiker, Afnan Alawi, Mohsen Al Atawi, Ibrahim Al Alwan
    Sudan J Paed. 2020; 20(1): 13-19
    » Abstract » doi: 10.24911/SJP.106-1587138942
    Cited : 4 times [Click to see citing articles]

  • Broad beans ( Vicia faba ) and the potential to protect from COVID-19 coronavirus infection
    Mutasim I. Khalil, Mustafa A. Salih, Ali A. Mustafa
    Sudan J Paed. 2020; 20(1): 10-12
    » Abstract » doi: 10.24911/SJP.1061585398078
    Cited : 4 times [Click to see citing articles]